机器人与骨肌肉质量比率与美国成年人全因和特定原因死亡率之间的关联:一项前性研究
Yuxin Fan1,2, Li Ding1, Wei Li1,3
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Diabetes, obesity & metabolism
|November 8, 2024
概括
较高的机器人/骨肌肉质量比率 (AGLR) 与死亡风险增加有关. 这项研究在美国国家健康和营养检查调查 (NHANES) 队列中发现,DXA测量的AGLR预测了更高的全因,癌症和心血管疾病死亡率.
科学领域:
- 人体生理学 人体生理学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 瘦身质量分布,特别是机器人/肌肉瘦身质量比 (AGLR),是身体组成的新兴指标.
- 通过双能X射线吸收计 (DXA) 评估的AGLR对死亡风险的预后价值仍然不完全理解.
研究的目的:
- 调查AGLR与所有原因,心血管疾病 (CVD) 和癌症死亡率的风险之间的联系.
- 评价AGLR作为一个新的指标,在一个大,多样化的人口死亡风险.
主要方法:
- 一项基于人口的队列研究,利用美国国家健康和营养检查调查 (NHANES) (2003-2006年和2011-2018年) 的数据.
- 包括18,542名20岁及以上的成年人,死亡率数据与国家登记册相关.
- 考克斯的比例危险回归模型和受限制的立方线被用来分析AGLR和死亡结果之间的关联.
主要成果:
- 在平均6.9年的随访期间,死亡人数为1412人,其中435人死于心血管疾病,340人死于癌症.
- 每次AGLR标准偏差的增加都与显著更高的风险相关:所有原因死亡率为1.53,癌症死亡率为1.56,心血管疾病死亡率为1.64.
- 这些关联在所有灵敏度分析中保持强,并在大多数子组中观察到.
结论:
- 通过DXA测量的安卓/gynoid瘦质量比 (AGLR) 是增加全因,癌症和心血管疾病死亡率的重要预测因素.
- AGLR代表了评估一般人口死亡风险的有价值指标.
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