关于COVID-19疫苗相对有效性的比较研究方法:系统性审查
Erdenetuya Bolormaa1, Jiae Shim2, Young-Sook Choi2
1Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Osong public health and research perspectives
|November 8, 2024
概括
很少有比较的COVID-19疫苗研究使用相对疫苗有效性 (rVE) 方法. 标准化rVE报告和共变量可以改善对疫苗性能的理解,并为公共卫生战略提供信息.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 已发表的比较2019年冠状病毒病 (COVID-19) 疫苗有效性 (VE) 的研究采用了各种方法方法.
- 需要对这些方法进行全面概述,以了解当前的研究实践.
研究的目的:
- 系统地审查和概述已发表的比较COVID-19疫苗有效性的研究中的方法方法.
- 确定用于疫苗有效性研究的共同研究设计,结果测量和分析方法.
主要方法:
- 2024年6月13日进行了系统的文献搜索,对mRNA与非mRNA和单价与双价COVID-19疫苗进行了比较研究.
- 数据提取包括研究设计,VE估计 (特别是相对VE或rVE),结果和共变量.
- 报告rVE的研究与没有报告的研究分开分析.
主要成果:
- 25篇文章比较了mRNA和非mRNA疫苗之间的rVE或单价和双价配方之间的rVE.
- 追溯的队列设计是常见的,感染是最常见的结果.
- 很少有研究 (2.0%) 对所有推的混变量进行了调整,许多研究没有报告rVE估计值.
结论:
- 在对比的COVID-19疫苗研究中,相对疫苗有效性 (rVE) 方法的纳入有限.
- 关于rVE的标准化报告和对共变量的一致调整对于进一步了解COVID-19疫苗性能至关重要.
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