多复合的胃肠道PCR面板用于评估急性白血病患者的腹

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Published on: July 22, 2011

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Clyde D Ford¹, Bert K Lopansri^2,3, Bradley D Hunter¹

¹Intermountain Acute Leukemia Program, LDS Hospital, Salt Lake City, UT, USA.

Infection control and hospital epidemiology

|November 8, 2024

概括

多复合肠道聚合酶链反应 (PCR) 面板 (MGPP) 测试对门诊急性白血病患者最有益. 住院治疗医院发作的腹的住院使用提供了有限的治疗优势,需要仔细解释结果.

科学领域:

临床微生物学和传染病.
血液学和瘤学血液学和瘤学
诊断的管理管理.

背景情况:

患有急性白血病的患者容易感染胃肠道感染.
多重复合的胃肠道聚合酶连锁反应 (PCR) 面板 (MGPP) 可快速检测多种病原体.
在这种人群中优化MGPP的使用对于有效治疗至关重要.

研究的目的:

在急性白血病患者中定义MGPP的诊断和治疗管理.
评估MGPP结果的指示,益处,最佳时间和解释.

主要方法:

对662名连续新诊断急性白血病患者的MGPP订单的回顾性审查.
分析了2015年6月至2024年5月期间对198名患者进行的305次MGPP测试.
数据来自区域急性白血病转诊中心收集的.

主要成果:

在17%的测试患者中,MGPP确定了病原体,其中Clostridioides difficile是最常见的 (78%).
门诊患者 (38%) 的阳性结果比住院患者更频繁 (38%).
在30个病例中,MGPP的结果导致了治疗变化,主要是C. 困难和吉亚迪亚兰布利亚.

结论:

MGPP测试在急性白血病患者的门诊环境中显示出有用性.
对于医院发作的腹的住院使用提供了最小的益处,需要谨慎的解释,特别是对于毒素阴性C. 困难的. 困难的.
MGPP的敏感性需要仔细考虑,以区分殖民和活跃感染.

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