CD163表达在未知的病因和SARS-CoV-2胎盘炎的慢性间炎中
1Department of Pathology, British Columbia Children's and Women's Hospitals, Vancouver, BC, Canada.
概括
原因不明的慢性间歇炎 (CIUE) 涉及具有抗炎M2表型的母性巨细胞. SARS-CoV-2 胎盘炎表现出类似的模式,表明怀孕并发症的共同途径.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 生殖医学 生殖医学
背景情况:
- 原因不明的慢性间歇性炎症 (CIUE) 的特征是母体炎症透,主要是巨细胞,在间歇空间.
- CIUE与不良妊娠结果有关,包括重复的妊娠流产.
- 在CIUE中报告了巨抗炎M2表型 (CD163+),可能调解病变发生.
研究的目的:
- 评估CIUE中的CD163表达,并将其与SARS-CoV-2胎盘炎进行比较.
- 为了调查CIUE和SARS-CoV-2胎盘炎之间的潜在病理生理相似之处.
- 利用自动化方法对CD163表达进行客观评估,尽量减少观察者变化.
主要方法:
- 在胎盘组织中对CD163表达的自动评估.
- 在CIUE,SARS-CoV-2胎盘炎和正常对照组织中对CD163表达的比较分析.
- 评估母体炎症透体内的巨细胞表型.
主要成果:
- 在CIUE中,母亲的炎症透体显示出CD163表达巨细胞的混合种群,与对照组相比,显著偏向于抗炎M2表型.
- 在SARS-CoV-2胎盘炎中,母体巨细胞中表现出类似的CD163表达模式.
- 与CIUE不同的是,SARS-CoV-2胎盘炎也显示了霍夫尔细胞中CD163表达的减少.
结论:
- CIUE母性透体表现出一种主要是抗炎的M2巨细胞表型.
- 在CIUE和SARS-CoV-2胎盘炎之间存在病理生理相似之处,可通过可比的CD163表达模式来表明.
- SARS-CoV-2 对霍夫尔细胞的明显影响表明病毒性胎盘炎的独特方面.
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