F2-异プロ斯坦与2型糖尿病中骨折风险增加有关
Bowen Wang1,2, Ruban Dhaliwal3,4, Susan K Ewing5
1Rensselaer - Icahn School of Medicine at Mount Sinai Center for Engineering and Precision Medicine, New York, NY.
The Journal of clinical endocrinology and metabolism
|November 8, 2024
概括
氧化应激,通过血F2-异质醇测量,显著增加骨折风险在老年人2型糖尿病 (T2D). 这种关联独立于骨矿物质密度,突出了与T2D相关的骨脆弱性的关键因素.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 2型糖尿病 (T2D) 与更高的骨折风险有关,即使有正常的骨矿物质密度 (BMD).
- 在T2D中增加的氧化应激可能会导致骨脆弱和糖尿病并发症.
研究的目的:
- 为了确定氧化应激的标记物血F2-异素与糖尿病老年人中发生骨折的风险是否相关.
- 在T2D的背景下,研究氧化应激标志物与骨折风险之间的关系.
主要方法:
- 一项观察性队列研究分析了来自健康,衰老和身体组成研究的数据.
- 包括有 (N=132) 和没有 (N=571) 的T2D的老年人 (70-79岁),与基线血F2-异质素测量.
- 事件临床骨折作为主要结局指标.
主要成果:
- 较高的血F2-异质水平与T2D组发生临床骨折的风险增加93%显著相关 (HR:1.93,p=0.002).
- 在非糖尿病组中没有观察到F2-异质与骨折风险之间的显著关联 (HR:0.98,p=0.79).
- 在T2D中,F2-异质与随时间的推移减少部总BMD相关,但与糖氧化或骨周转标志物无关.
结论:
- 血F2-异质素水平升高与糖尿病患者骨折风险增加有关.
- 这种关联独立于基线骨矿物质密度,表明氧化应激是T2D骨脆弱性的关键因素.
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