基准剂量二氧化基于怀孕期糖尿病使用联合暴露统计方法和优化生理学基础的毒动力学模型
Tao Ying1, Xin Liu2,3, Lei Zhang2
1School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China.
Environment & health (Washington, D.C.)
|November 8, 2024
概括
这项研究将二氧化碳暴露与妊娠糖尿病 (GDM) 联系起来. 它确立了对二氧化的基准剂量和每日暴露值,考虑到对其他化学品的同时暴露,以防止GDM.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 二氧化物是无处不在的内分泌干扰物质.
- 评估同时暴露效应和基准剂量是一项挑战.
- 孕期糖尿病 (GDM) 是一个重要的妊娠并发症.
研究的目的:
- 评估二氧化碳暴露和GDM之间的关系.
- 在共暴露场景中计算二氧化的基准剂量 (BMD).
- 通过使用生理学基础的毒动力学 (PBTK) 模型来推导每日暴露值.
主要方法:
- 嵌套病例控制研究 (77个GDM病例,154个对照).
- 测量了二氧化类化合物 (DLC),PFAA,PBDE和ndl-PCB的血清水平.
- 贝叶斯机器内核回归 (BKMR),探针,物流模型和PBTK模型用于分析.
主要成果:
- 总二氧化毒性等价值 (TEQ) 量最高的个体具有显著更高的GDM几率 (OR,8.87).
- 二氧化物TEQ和BDE-153被确定为关键的有影响力的化合物.
- 考虑到BDE-153的同时暴露,BMD10和BMDL10分别为3.71和3.46 pg TEQ/g脂肪.
- 估计每日暴露值低于4.34 pg TEQ 千克-1 身体周-1 以避免对GDM有害的血清度.
结论:
- 暴露于二氧化物与增加GDM风险有关.
- 同时接触其他化学物质,如BDE-153,会影响二氧化的作用.
- PBTK模型和共同暴露的统计方法对于准确的风险评估和设定暴露限值至关重要.
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