在接受 pembrolizumab 治疗的患者中,延迟发作的自身免疫性胆管炎
Joshua Newington1, Daniel Patterson2, Pilar Sanchez3
1Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0SP, United Kingdom.
BJR case reports
|November 8, 2024
概括
一名患者在接受了非小细胞肺癌的 pembrolizumab 治疗后发生了自身免疫性胆管炎. 诊断被推迟了,原因是现在恐惧症和COVID-19大流行.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 布罗利祖马布是一种用于非小细胞肺癌的免疫疗法.
- 自身免疫性胆管炎是一种罕见但严重的不良事件,与免疫检查点抑制剂有关.
- 延迟诊断可能会导致严重的肝损伤和患者的不良结果.
研究的目的:
- 在 pembrolizumab 治疗后报告自身免疫性胆道炎的病例.
- 突出诊断的挑战和贡献因素在这种情况下.
- 强调早期识别和管理免疫相关不良事件的重要性.
主要方法:
- 一个70多岁的女性患者的病例报告.
- 对临床表现,诊断工作和治疗过程的审查.
- 对延迟诊断的潜在因素进行分析.
主要成果:
- 患者在完成35个周期的pembrolizumab治疗非小细胞肺癌后一年发生了自身免疫性胆管炎.
- 诊断最初错过了,随后被推迟了.
- 患者的广场恐惧症和COVID-19大流行病被确定为导致诊断延迟的因素.
结论:
- 在非小细胞肺癌的 pembrolizumab 治疗后,自身免疫性胆管炎可能发生晚期.
- 焦虑和外部因素,如COVID-19流行病,可以阻碍及时诊断与免疫相关的不良事件.
- 在接受 pembrolizumab 治疗的患者中,对自身免疫性胆管炎的警至关重要,即使治疗结束后很长时间.
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