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糖尿病视网膜病变患者的白质功能和网络异常
Yu-Lin Zhong1, Rui-Yang Hu2, Yuan-Zhi He3
1Department of Ophthalmology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|November 8, 2024
概括
糖尿病视网膜病变 (DR) 显著改变白质功能和网络连接. 这些变化影响连接视觉和感官运动网络的途径,可以通过先进的成像技术检测到.
科学领域:
- 神经成像是一种神经成像.
- 白色物质 完整性 完整性
- 糖尿病神经病变 - 糖尿病神经病变
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病的并发症,影响眼睛.
- 白质 (WM) 变化可能发生在DR患者身上.
- 了解WM变化对于全面的患者护理至关重要.
研究的目的:
- 调查DR患者和健康对照者 (HC) 之间的白质 (WM) 功能和网络连接的差异.
- 分析与DR相关的WM网络中的特定变化.
主要方法:
- 包括46名DR患者和43名年龄/性别匹配的HC参与者.
- 利用扩散张力成像 (DTI) 度量,例如低频波动的分数振幅 (fALFF),区域同质性 (ReHo) 和中心度 (DC).
- 用人支持矢量机 (SVM) 对分类准确性的分析.
主要成果:
- 患有DR的患者表现出WM功能发生变化,中小脑脚和大脑体基因中DC增加.
- 在特定路径中观察到更高的fALFF值,而在左后丘脑辐射中观察到较低的ReHo值.
- 根据WM测量,SVM分类在区分DR和HC方面取得了高准确度 (81-89%),具有显著的AUC值.
结论:
- 糖尿病视网膜病变与异常的白质功能改变有关.
- 这些变化特别影响连接视觉网络与感觉运动网络的光纤通路.
- WM成像为DR相关的神经变化提供了潜在的生物标志物.
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