5%利多卡因治疗的石膏在膝关节置换后预防慢性术后疼痛的影响:随机双盲安慰剂对照试验的协议
Junpeng Yuan1, Huichan Xu1, Jiongjiong Guo1
1Department of Pain Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Frontiers in pharmacology
|November 8, 2024
概括
这项研究调查了5%的利多卡因治疗石膏 (LP5) 是否可以预防膝关节关节整形术后的慢性术后疼痛 (CPSP). 结果将指导进行这种常见手术的患者的疼痛管理策略.
科学领域:
- 麻醉学和疼痛管理
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于人口老龄化,膝关节关节整形越来越多地进行.
- 慢性术后疼痛 (CPSP) 影响了膝关节节整形术后的大量患者 (高达30%).
- 对CPSP的有效预防策略对于改善患者的治疗结果至关重要.
研究的目的:
- 为了评估5%的利多卡因药物治疗石膏 (LP5) 在膝关节关节整形术后预防CPSP的疗效.
- 评估LP5在多模式止痛药的辅助使用时的安全性.
- 为临床医生提供关于LP5在治疗关节形成术后疼痛中的作用的强有力的证据.
主要方法:
- 这是一项双中心,随机,双盲,安慰剂控制的试验,涉及128名接受膝关节关节整形手术的患者.
- 参与者接受了手术前和手术后三天的LP5或安慰剂贴片,以及多式止痛药 (flurbiprofen axetil和患者控制的sufentanil).
- 测量的主要结局是3个月后WOMAC的疼痛分级;许多次要和安全结局也被评估.
主要成果:
- 该研究旨在确定LP5是否与安慰剂相比显著降低了慢性术后疼痛的发生率或严重程度.
- 分析将包括WOMAC评分,神经病痛评估 (LANSS),生活质量 (SF-36) 和各种与疼痛相关的次要结果.
- 包括血液动力学事件和局部反应在内的安全数据将被仔细收集和分析.
结论:
- 预计这些发现将澄清LP5作为CPSP在膝关节关节整形患者的预防措施的有效性.
- 这项研究旨在将LP5作为骨科手术患者多模式疼痛管理的有价值工具.
- 该研究将为优化疼痛控制和改善膝关节置换手术后恢复提供高质量的证据.
相关概念视频
Local Anesthetics: Clinical Application as Epidural Anesthesia
414
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
414
Local Anesthetics: Clinical Application as Spinal Anesthesia
584
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
584
Local Anesthetics: Pharmacokinetics
735
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
735
Local Anesthetics: Common Agents and Their Applications
408
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
408
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
976
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
976
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
365
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
365


