在前列腺癌中,雄激素缺乏治疗期间与生存相关的身体组成变化的值
Pin-Chi Chen1, Pai-Kai Chiang2,3,4, Jhen-Bin Lin5
1School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
European urology open science
|November 8, 2024
概括
前列腺癌患者的雄激素剥夺疗法 (ADT) 可以导致显著的身体组成变化. 确定肌肉损失和脂肪增加的门可以帮助预测死亡风险并指导干预措施.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 身体组成分析 身体成分分析
背景情况:
- 雄激素剥夺疗法 (ADT) 是前列腺癌的标准治疗方法.
- 众所周知,ADT会导致身体组成的不良变化,包括肌肉损失和脂肪质量的增加.
- 与患者存活率相关的这些变化的具体值仍然不清楚.
研究的目的:
- 为了确定在ADT期间身体组成变化的关键值.
- 确定与所有原因死亡率相关的骨肌肉指数 (SMI),皮下脂肪组织指数 (SATI) 和内脏脂肪组织指数 (VATI) 的特定变化.
- 为了验证这些值在接受ADT的前列腺癌患者的临床应用.
主要方法:
- 利用了538名前列腺癌患者的计算机断层扫描 (CT) 扫描 (衍生和验证队列).
- 在基线和ADT启动6个月后测量SMI,SATI和VATI.
- 采用沙普利添加式解释 (SHAP) 来确定最佳值和考克斯比例危险模型进行验证.
主要成果:
- 身体成分变化 (SMI,SATI,VATI) 是所有原因死亡率的关键预测因素.
- 确定了重要的值:SMI损失 (≥4.0%),SATI增益 (≥15.0%),和VATI增益 (≥12.0%).
- 这些值独立地与死亡风险增加有关 (例如,SMI损失HR6.79,p<0.001).
结论:
- 在ADT期间确立了肌肉损失和脂肪增加的具体值.
- 这些值可以识别前列腺癌患者的死亡风险较高.
- 结果可以指导有针对性的干预措施,以改善身体组成和患者的结果.
相关概念视频
01:28Menopause
140
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
140
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:20Disorders of the Male Reproductive System
337
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
337
01:27Signs of Puberty
263
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
263
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
01:26Testosterone: Functions and Regulation
560
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
560