不丹多药耐药结核病的高发病率:基于国家结核病监测数据的队列研究
Thinley Dorji1,2, Karchung Tshering3, Lila Adhikari3
1Kanglung Hospital, Trashigang, Bhutan.
IJID regions
|November 8, 2024
概括
多抗药结核病 (MDR-TB) 是不丹的一个重大挑战. 这项研究在10.6%的病例中发现了MDR-TB,在特定地区和年轻人,女性和先前接受过治疗的患者中患病率更高.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 多药耐药结核病 (MDR-TB) 构成了全球重大健康威胁,复杂化了治疗和控制工作.
- 关于不丹耐药结核病 (TB) 患病率和风险因素的数据有限,这阻碍了针对性的干预.
研究的目的:
- 估计不丹的MDR-TB和前广泛耐药性结核病 (XDR-TB前) 的发生率.
- 确定与不丹人口中MDR/XDR前结核病相关的潜在风险因素.
主要方法:
- 来自结核病信息监测系统 (2018-2021) 的国家结核病数据的分析.
- 包括所有针对耐药性测试的结核病例.
- 应用多重物流回归来确定MDR/XDR前TB的风险因素.
主要成果:
- 这项研究在测试样本中发现了10.6%的MDR-TB,3.5%的异酸耐药TB和0.61%的XDR-TB.
- 在Thimphu,Samtse和Sarpang地区观察到MDR/RR-TB/XDR-TB前的高发病率.
- 患MDR/XDR前结核病的危险因素包括年龄较小 (18-39岁),女性性别以及先前的结核病治疗.
结论:
- 在特定地区的MDR-TB的高负担需要诊断设施的去中心化,以便快速识别和管理.
- 针对高风险人群的有针对性的跟进和监测对于不丹有效的结核病控制至关重要.
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