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在极度早产的男性婴儿中,产后的雄激素失调
Anders K Nilsson1, Ulrika Sjöbom1,2, Andreas Landin3
1Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-405 30, Sweden.
极度早产的男性婴儿在出生后表现出早期和升高的雌激素水平,这表明下丘脑-垂体-阴茎轴的激活. 这种早期的激素激增可能会影响神经发育,需要进一步调查.
科学领域:
- 新生儿内分泌学 新生儿内分泌学
- 神经发育研究的神经发育研究.
- 儿科内分泌学 儿科内分泌学
背景情况:
- 神经发育障碍在极度早产的婴儿中很常见,尤其是男性.
- 脑下垂体 - 脑下垂体 - 淋巴结核 (HPG) 轴的过度活化是一个可疑的,但尚未研究的原因.
研究的目的:
- 为了确定雄性激素水平及其随时间变化的极度早产婴儿男性.
- 在这个人群中调查HPG轴的早期激活.
主要方法:
- 一个观察性队列研究的婴儿男婴出生在22.8-27.9周怀孕年龄.
- 对带血和产后血 (11周前) 进行丸激素,二激素 (DHT),性激素结合球蛋白 (SHBG),卵泡刺激激素 (FSH) 和黄素激素 (LH) 的分析.
- 使用气体染色体质谱,酶相关免疫吸收剂测定和Luminex xMAP多重测定进行激素量化.
主要成果:
- 在0日的产后雄激素 (和DHT) 水平明显高于带血水平,并且在早期达到峰值.
- 到第五天,雄激素水平迅速下降,并保持相对稳定,但比子宫中的水平高约6倍.
- 卵泡刺激激素和黄素化激素表现出与雄激素类似的产后模式,而性激素结合型球蛋白增加,减少生物可用丸激素.
结论:
- 在极度早产的男性中,下丘脑-垂体-腺轴在出生后立即被激活,导致早期的雄激素脉冲.
- 在关键的神经发育窗口期间,这种过早的,高水平的雄激素暴露需要进一步研究其长期影响.
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