经历歧视与肠道微生物组和转录组的改变有关
Tien S Dong1,2,3,4,5, Simer Shera5, Kirstin Peters5
1G. Oppenheimer Center for Neurobiology of Stress and Resilience at UCLA, Los Angeles, CA, United States.
Frontiers in microbiology
|November 8, 2024
概括
歧视显著影响肠道健康,改变微生物组合和基因表达. 一种多层次的方法准确地确定了歧视状况,突出了与这种心理社会压力因素相关的生物变化.
科学领域:
- 心理社会压力因素 心理社会压力因素
- 肠道微生物组研究研究
- 多个omics的多个omics.
背景情况:
- 歧视是已知的心理社会压力因素,有记录的负面健康影响.
- 这项研究研究了歧视对肠道健康的影响,包括微生物组合和基因表达.
- 采用多组的方法来识别歧视的生物标志物.
研究的目的:
- 探索歧视对肠道微生物组合和预测的元基因组差异的影响.
- 分析转录组资料并确定与歧视相关的基因表达模式.
- 评估多组方法在预测个人歧视状况方面的潜力.
主要方法:
- 参与者被分为高或低的歧视群体,使用日常歧视量表.
- 分析了便样本的微生物组合 (α和β多样性) 和差异丰度.
- 进行RNA测序以进行元转录组学,并使用随机森林模型进行多原子分析.
主要成果:
- 高歧视与肠道微生物群物种丰富度增加和β多样性改变有关.
- 特定的微生物种群 (Prevotella, Ruminococcaceae) 在高分辨率组中不那么丰富.
- 一个多原子随机森林分类器在区分歧视水平方面取得了高准确性 (AUC=0.91).
结论:
- 歧视显著影响肠道健康,影响微生物组合,基因表达和功能途径.
- 歧视与内部的生物学变化有关,这些变化可能会导致负面的健康结果.
- 这些发现为研究减轻歧视对健康影响的新途径开辟了道路.
更多相关视频
相关概念视频
Anatomy of the Intestines
71.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.4K
What is Monogastric Digestion?
70.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.6K
Bacterial Flora of the Large Intestine
388
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
388
Irritable Bowel Syndrome I: Introduction
248
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
248
MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K


