健康人群的口腔肠道微生物群关系:确定环境和年龄组之间的共享细菌
Carolina F F A Costa1,2, Teresa Correia-de-Sá2,3, Ricardo Araujo2
1ICBAS - Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal.
Frontiers in microbiology
|November 8, 2024
概括
一项研究发现,在健康个体中,少量细菌在口腔和肠道之间共享,这表明口腔到肠道的转移可能从童年开始就很常见. 这项研究强调了口腔和肠道微生物群在整个生命的相互联系.
科学领域:
- 微生物学 微生物学
- 人类微生物组研究研究
- 胃肠病学 胃肠病学
背景情况:
- 口腔和肠道微生物群之间的关系尚未得到充分研究,特别是在健康个体中.
- 在健康状态下,口腔和肠道之间的细菌转移证据有限.
- 了解跨生命阶段的口腔肠道微生物群动态至关重要.
研究的目的:
- 调查健康儿童和成人口腔和肠道之间共享的微生物群的存在和程度.
- 在健康人群中探索口腔肠道细菌转移的潜在路径和流行率.
- 识别可能在口腔和肠道环境中存在的特定细菌种群.
主要方法:
- 从39名儿童和97名健康成年人那里收集了唾液和便样本.
- 进行了细菌16S核糖体RNA基因V4区域的测序.
- 安普利康序列变异 (ASV) 分析用于识别和量化微生物群落.
主要成果:
- 在相同个体的口腔和肠道样本中发现了61个共享的ASV (1.6%的总检测量).
- 在这些共享的ASV中,有26个存在于儿童和成年人中,表明潜在的终身殖民.
- 62%的共享ASV在口腔中更为丰富,这表明口腔到肠道转移是主要的途径.
结论:
- 从口腔到肠道的细菌转移在健康个体中可能比以前认为的更为常见.
- 某些口腔细菌可能会在肠道中建立持续的殖民地,可能从童年开始.
- 这项研究提供了在不同生命阶段的健康人群中持续存在口腔肠道微生物轴的证据.
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