苏弗雷克桑和伦博雷克桑的短期有效性和安全性:一项回顾性研究
Koki Mori1, Michio Kimura1, Eiseki Usami1
1Pharmacy, Ogaki Municipal Hospital, Ogaki, JPN.
Cureus
|November 8, 2024
概括
伦博雷克桑在治疗失眠的最初几天里,比苏沃雷克桑更有效地改善了睡眠时间. 虽然这两种素受体对抗剂 (ORA) 都比二zepines更安全,但lemborexant对睡眠持续时间的早期影响更强.
科学领域:
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
- 临床研究 临床研究
背景情况:
- 长期使用二二类药物对失眠治疗有风险.
- 素受体对抗剂 (ORA) 为治疗失眠提供了更安全的替代方案.
- 比较新的ORAs,如suvorexant和lemborexant对于临床实践至关重要.
研究的目的:
- 为了比较suvorexant和lemborexant在治疗失眠方面的疗效和安全性.
- 评估早期睡眠时间作为主要疗效终点.
- 评估跌倒发生率作为一个关键的安全结果.
主要方法:
- 一项回顾性研究包括了105名新处方suvorexant或lemborexant的患者.
- 排除标准包括同时服用睡眠药物或抗精神病药物.
- 主要终点:睡眠时间 (前3天);次要终点:跌倒发生率.
主要成果:
- 与基线相比,lemborexant在所有三天都显著增加了睡眠时间;suvorexant在第二天和第三天显著增加了睡眠时间.
- 伦博雷克桑在第一天的睡眠时间显著增加 (5.93±1.90小时) 与苏博雷克桑 (5.10±1.84小时) 相比.
- 在两组中,跌倒发病率都很低 (0%为suvorexant,5.3%为lemborexant),没有统计学上显著的差异.
结论:
- 与suvorexant相比,Lemborexant在治疗的第一天对睡眠时间产生了更强大的影响.
- 这种增强的疗效可能归因于勒博雷克桑特对素2受体的强烈抑制.
- 这两种ORA都代表了对二类药物治疗失眠的可行的替代品,而勒博雷克桑特显示出更强的初始睡眠诱导.
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