喷雾干燥的多素B脂质体用于吸入,对抗阴性细菌
Thaddeus Harrison Gugu1,2, Emmanuel Maduabuchi Uronnachi2,3, Ekawat Thawithong2
1Department of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka, Nigeria.
Pharmaceutical development and technology
|November 8, 2024
概括
这项研究开发了脂质体干粉吸入聚米辛B (PMB),降低毒性并对抗耐药性. 这种新型配方在肺部模型中证明了对细菌的安全性和有效性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 抗菌研究 抗菌研究
背景情况:
- 聚米辛B (PMB) 具有显著的毒性和细菌耐药性,限制了其临床应用.
- 吸入疗法为局部药物输送到肺部提供了一个有前途的途径,可能减轻全身毒性.
研究的目的:
- 开发和描述polymyxin B (PMB) 的脂质体干粉配方,用于吸入.
- 评估吸入性脂质体PMB对肺部细菌感染的安全性和有效性.
主要方法:
- 使用薄膜水化和喷雾干燥的PMB的脂质体干粉配方.
- 物理性质的表征,空气动力学性能 (NGI) 和体外药物释放.
- 细胞毒性 (MTT试验) 和抗菌活性 (生物试验,流细胞计) 的评估.
主要成果:
- 喷雾干燥的脂质体呈现出259.83518.73nm之间的粒子大小和正泽塔电位.
- 没有观察到PMB和辅料 (FTIR) 之间的化学相互作用;粉末是无形的 (DSC) 和球形的 (SEM).
- 空气动力学直径为1.722.75nm,微粒分数为2526% (FPF);在2小时内释放90.3%的PMB;有效杀死*Pseudomonas aeruginosa*和*Escherichia coli*.
结论:
- 脂质体干粉吸入是一种有效的PMB输送系统.
- 该配方显示了降低的毒性和强大的抗微生物活性对关键的肺病原体.
- 这种方法为克服PMB毒性和呼吸道感染中的细菌耐药性提供了一个有希望的策略.
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