与代谢功能障碍相关的脂肪性肝病 (MASLD) 的管理策略
Naim Alkhouri1, Mazen Noureddin
1Arizona Liver Health, Tucson Liver Clinic, 1601 North Swan Road, Tucson, AZ 85712.
The American journal of managed care
|November 8, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和其渐进的形式,代谢功能障碍相关的脂肪性肝炎 (MASH),正在引起越来越多的健康问题. 早期查和治疗对于管理MASH及其相关风险至关重要.
科学领域:
- 肝病学和代谢疾病研究.
背景情况:
- 与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 涉及具有代谢风险因素的肝脂肪酸.
- 代谢功能障碍相关的脂肪肝炎 (MASH) 是MASLD的渐进形式,其特征是炎症和肝细胞损伤.
- MASH影响美国成年人的1-6%并且预计会增加,通常与2型糖尿病和心血管疾病同时发生.
研究的目的:
- 要突出 MASLD 和 MASH 的不断变化的理解和命名.
- 强调及时诊断的重要性以及MASH的新治疗方法的可用性.
- 鼓励针对MASH风险因素的个体进行主动查.
主要方法:
- 对MASLD和MASH的当前文献和诊断指南的审查.
- 讨论病理生理机制和导致肝损伤的因素.
- 检查新兴的诊断工具和治疗干预措施,包括FDA批准的治疗方法.
主要成果:
- MASLD是由肝硬化和代谢风险因素定义的;MASH涉及炎症和损伤.
- MASH的患病率很大,预计会增加,并有常见的并发症.
- Resmetirom是一种THR-β激动剂,是经批准的肝脏治疗中度至重度纤维化MASH的治疗方法.
结论:
- 早期检测和干预对于阻止MASH进展至关重要.
- 患有风险因素的患者应寻求医疗评估进行MASH查.
- 像resmetirom这样的向疗法的出现标志着MASH管理的重大进步.
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