β2-.

Tala Fnu1,2, Peiguo Shi3,4, Wanwei Zhang5

  • 1Department of Medicine, Columbia Center for Human Development, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

Cancer discovery
|November 8, 2024
PubMed
概括

准交感神经或ADRB2受体可以减缓小细胞肺癌 (SCLC) 的进展. 抑制ADRB2会破坏PKA信号传递,为侵袭性SCLC提供了一个新的治疗策略.

相关概念视频

Sympathetic Signaling01:32

Sympathetic Signaling

Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
885
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

Overview
94.5K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:28

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.2K
Sympathetic Division of the ANS01:19

Sympathetic Division of the ANS

The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
1.7K
Sympathetic Activation01:17

Sympathetic Activation

The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.0K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
1.6K