在中度语言缺陷的自闭症子组中,语言能力的神经解剖学基础
Yaqiong Xiao1, Ningxuan Zhang2, Kaiyu Huang3
1Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, 518107, China. xiaoyq@suat-sz.edu.cn.
European child & adolescent psychiatry
|November 8, 2024
概括
神经成像揭示了自闭症谱系障碍 (ASD) 和中度语言缺陷的儿童的独特大脑结构. 这些发现突出了ASD语言异质性的神经解剖基础.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 在儿童的语言能力中呈现出显著的异质性.
- 虽然已知ASD中语言缺陷的神经相关性,但神经解剖学的基础仍然不清楚.
- 在ASD早期语言发展需要进一步调查大脑结构差异.
研究的目的:
- 研究ASD儿童与典型发育 (TD) 儿童之间大脑体积的神经解剖学差异.
- 探索皮质灰质体积与不同ASD亚组语言能力之间的关系.
- 阐明ASD幼儿语言缺陷的神经解剖学的基础.
主要方法:
- 分析了67名患有自闭症的中国儿童和37名TD儿童 (年龄为1.5-6.5岁) 的MRI数据.
- 将ASD参与者分为中度 (ASD中度) 和严重 (ASD严重) 语言缺陷子组.
- 比较了TD和ASD亚组之间的大脑体积,并检查了灰质体积和语言分数之间的相关性.
主要成果:
- 在TD和ASD中度子组之间发现了灰色和白质量量的显著差异.
- 灰色质量和语言分数之间的相关性仅在ASD中度子组中观察到.
- 在上回,海马体和下叶中发现了积极的关联;在前骨中发现了负面的关联.
结论:
- 提供了关于ASD和中度语言缺陷儿童语言能力的神经解剖学的基础的新证据.
- 提供了关于自闭症谱系障碍人口中语言缺陷异质性的新见解.
- 表明特定的大脑区域与ASD小组儿童的语言功能有关.
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