症状不复杂的直体疾病中的肠道微生物群根据腹痛的严重程度分层分层
Antonio Tursi1,2, Silvia Turroni3, Rudi De Bastiani4
1Territorial Gastroenterology Service, Barletta-Andria-Trani Local Health Agency, Andria.
European journal of gastroenterology & hepatology
|November 8, 2024
概括
症状不复杂的分歧性疾病 (SUDD) 显示特定的肠道细菌与腹痛严重程度有关. 肠道微生物群概况可能有助于通过分层和指导治疗来管理SUDD患者.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 临床研究 临床研究
背景情况:
- 症状不复杂的分歧性疾病 (SUDD) 可能涉及肠道失调.
- 目前对SUDD肠道微生物群的研究规模很小,结果不一致.
- 关于SUDD便微生物群的初级保健数据有限.
研究的目的:
- 在患有症状无并发性分歧性疾病 (SUDD) 的患者中分析便微生物群.
- 为了比较SUDD患者和无症状分泌腺瘤 (AD) 控制者之间的肠道微生物群.
- 调查肠道微生物组成和SUD的腹痛严重程度之间的关联.
主要方法:
- 在72名SUDD患者和30名AD对照患者的便微生物群的回顾性分析.
- 使用16S rRNA基因测序 (隐含) 的微生物群概况.
- 微生物种类和视觉模拟量表 (VAS) 疼痛评分之间的相关性分析.
主要成果:
- 在SUDD和AD组之间,α或β多样性没有显著差异.
- 在SUDD患者中,Streptococcaceae,Alistipes,Agathobacter和Butyricimonas的相对丰度较高.
- 肠道微生物群的组成因腹部疼痛的严重程度 (VAS分数) 而异:轻度 (Bifidobacterium,Dorea),中度 (Proteobacteria,Blautia) 和严重 (Prevotellaceae,Megasphaera).
结论:
- 特定的肠道微生物种类与SUDD有关,根据腹痛强度的变化.
- 这些发现有助于对SUDD的生态理解.
- 肠道微生物群的分析可能有助于临床管理,包括 SUDD 的患者分层和治疗选择.
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