微生物的新陈代谢破坏了细胞因子的活动,以影响宿主免疫反应
Eleanor K P Marshall1,2, Catarina Nunes1,2, Sophie Burbaud3,4
1Centre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.
概括
菌根杆菌需要阿斯巴拉金运输的致病性,影响宿主免疫反应. 限制阿斯巴拉金可以通过调节免疫信号和胰岛素通路来增加宿主生存率.
科学领域:
- 宿主-病原体相互作用
- 微生物的新陈代谢
- 这是天生的免疫力.
背景情况:
- 宿主和病原体的代谢状态极大地影响感染的结果.
- 病原体必须获得宿主代谢资源才能生存.
- 了解这些相互作用是开发新治疗方法的关键.
研究的目的:
- 调查阿斯巴拉金运输在 * Mycobacterium abscessus * 致病性中的作用.
- 为了阐明M.的代谢状态对Drosophila melanogaster*宿主反应的影响.
主要方法:
- 对M.的基因操纵 (MAB_1132c淘汰).
- 感染 *Drosophila melanogaster* 与野生类型和淘汰菌株的感染.
- 对宿主生存,细菌负载,免疫基因转录和胰岛素信号的分析.
主要成果:
- MAB_1132c,一个阿斯巴拉金转运体,对于M.的致病性至关重要.
- 在 *M. abscessus* 中限制阿斯巴拉金可以增加宿主生存率,而不会改变细菌负载.
- 降低阿斯巴拉金的可用性会抑制宿主天生的免疫反应,包括抗微生物的产生和胰岛素信号的破坏.
结论:
- 在 *M. abscessus* 中的阿斯巴拉金运输对毒性至关重要,而不是体内复制.
- 感染前的阿斯巴拉金可用性显著调节宿主免疫反应和生存.
- 针对微生物营养获取提供了一个潜在的策略来控制感染.
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