相关实验视频
Updated: Jun 30, 2026

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
Published on: August 2, 2022
抗凝血患者自身血清撕裂的产生
Maya T Harrington1, Leon Su2, Jill Adamski2
1Mayo Clinic School of Medicine, Scottsdale, AZ.
自主血清撕裂 (AST) 生产可能会失败,如果血清固化. 这项研究发现,服用抗凝血或抗血小板药物或最近感染的患者患AST生产失败的风险更高.
科学领域:
- 眼科医生 眼科 眼科
- 临床药房 临床药房
- 血液学 血液学 血液学
背景情况:
- 自主血清撕裂 (AST) 对于治疗严重干眼疾病至关重要.
- 已经报告了生产失败,其特点是血清固化.
- 识别AST生产失效的风险因素对于一致的治疗至关重要.
研究的目的:
- 确定与无法合成自身血清撕裂 (AST) 相关的风险因素.
- 为了调查在AST准备过程中血清凝固的原因.
主要方法:
- 从2019年1月到2022年12月接受AST的99名患者的回顾性图表审查.
- 对患者人口统计,诊断,药物,实验室结果和抽血事件的分析.
- 实验室和药房协议的观察后期生产问题.
主要成果:
- 在4名患者中发生了10次血清凝块事件,主要是患有慢性眼球移植与宿主疾病或Sjögren综合征的患者.
- 80%的发作与最近的系统性感染或肺栓塞有关.
- 所有受影响的患者都服用抗血小板和/或抗凝血药物.
结论:
- 假设在离心前休息期内凝血不足会导致血清凝固.
- 抗凝血或抗血小板药物可能会增加不充分凝血的风险.
- 建议建议采集管的休息时间为60分钟,即使是服用这些药物的患者也是如此.
更多相关视频
03:55Production of Modified Autologous Conditioned Serum and Ex Vivo Assessment of Its Healing Potential in Murine Corneal Epithelium
Published on: March 24, 2023
09:04Author Spotlight: Isolating Biomolecules from Mouse Tears — A Methodology for Molecular Analysis and Biomarker Research
Published on: July 19, 2024
相关概念视频
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Clot Retraction and Fibrinolysis
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.