先天性细胞巨乳病毒感染和听力损失:是时候进行查了
Javier K Nishikawa1, Pablo J Sánchez2
1Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
概括
先天性细胞巨乳病毒 (CMV) 感染是新生儿听力损失的主要原因之一. 建议对早期检测和治疗进行普遍查,以改善结果.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 听力学 听力学是指听力学.
背景情况:
- 在全球范围内,先天性细胞巨乳病毒 (CMV) 感染是感觉神经听力损失的主要非遗传原因.
- 大多数受感染的新生儿无症状,但有相当数量的新生儿会出现听力损失,无论是在出生时还是在以后.
- 在生命的第一个月内,早期的抗病毒治疗 (ganciclovir/valganciclovir) 改善了听力学结果.
研究的目的:
- 强调迫切需要及时识别具有先天性CMV感染的新生儿.
- 评估当前针对性查方法的有效性.
- 倡导对先天性CMV感染进行普遍查.
主要方法:
- 关于先天性CMV感染及其后果的当前文献的综述.
- 对针对性新生儿CMV听力查方法的局限性进行分析.
- 考虑基于患病率,可用的工具和治疗选择的普遍查.
主要成果:
- 针对新生儿听力屏幕的新生儿的有针对性的查错过了大约40%的CMV相关听力损失的儿童.
- 遗传性CMV感染很普遍,导致严重的听力损伤.
结论:
- 对先天性CMV感染进行普遍查的方法是最优的.
- 普遍查有助于早期诊断,及时的抗病毒治疗和听力障碍的管理.
- 早期干预对于改善受影响婴儿的长期听力学结果至关重要.
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