超血症与严重老年败血症患者的死亡率有关
Xu Liu1, Yalin Hong2, Bingchen Li1
1Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
PloS one
|November 8, 2024
概括
过高血量,或高血清,在老年败血症患者中延长. 血清水平高于154.9 mmol/L的峰值预测这些患者的28天死亡率更高.
科学领域:
- 关键护理医学 关键护理医学
- 老年病的医生 老年病的医生
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 超血是重症患者常见的电解质失衡.
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染反应失调引起的.
- 高血和老年败血症患者的死亡率之间的关系需要进一步调查.
研究的目的:
- 为了研究高血和28天死亡率之间的联系,在老年患有败血症的患者中.
- 为了评估血清水平在这个患者群体中预后的预测值.
主要方法:
- 对179名老年患者 (≥65岁) 进行了回顾性观察研究,这些患者血清含量升高.
- 患者根据败血症3.0标准被分为败血症和非败血症组.
- 用ROC曲线和卡普兰-梅尔生存分析分析了临床数据,包括血清水平,APACHE II分数和死亡率.
主要成果:
- 与非败血症患者相比,败血症患者的血清升持续时间较长.
- 峰值血清水平 (≥154.9 mmol/L) 与更高的7日和28日死亡率有显著的关联.
- 卡普兰-梅尔分析显示,高峰血清≥154.9 mmol/L的患者的中位生存时间较短.
结论:
- 老年败血症患者经历了长时间的血清水平升高,波动相对较小.
- 血清水平的峰值是老年败血症患者28天死亡率的有价值预测指标.
- 这一发现强调了监测和管理这种脆弱人群中高血症的重要性.
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