一个针对内源逆转录病毒的B细胞屏幕识别了糖甘反应性IgM,该IgM识别了广泛的包裹病毒
Yexin Yang1, Rebecca S Treger1, Juan Hernandez-Bird1
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Science immunology
|November 8, 2024
概括
来自B-1细胞的天然IgM抗体向内源逆转录病毒 (ERV) 和其他包裹病毒. 这种先天免疫机制使用生殖系编码的抗体来控制ERV的出现.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 内生逆转录病毒 (ERV) 是古代遗传元素,包括大部分脊椎动物基因组.
- 具有完整编码潜力的ERV可以重新激活,对宿主生物构成潜在威胁.
- B细胞在抗ERV免疫力中的作用尚未完全理解.
研究的目的:
- 研究B细胞对宿主免疫力对内源逆转录病毒 (ERVs) 的贡献.
- 为了确定特定的B细胞群和参与抗ERV免疫的抗体反应.
主要方法:
- 使用抗原诱导策略来分离对ERV表面抗原有反应性的B细胞.
- 分析了ERV反应性B-1细胞的B细胞受体谱.
- 研究了对ERV糖蛋白和其他包裹病毒的抗体反应性.
主要成果:
- 在原始小鼠中确定了表达生殖系编码的天然IgM抗体的ERV反应B-1细胞.
- 在ERV-反应性B-1细胞中发现了特定IghVH基因的增加使用,产生针对ERV糖蛋白N-乙糖胺的抗体.
- 证明这些抗体激活了对抗ERV反应的补充通路,并与其他包裹病毒进行交叉反应,但不是自我蛋白质.
结论:
- 生殖系编码的天然IgM抗体提供了对内源逆转录病毒 (ERVs) 的天生的抗病毒防御.
- 这种抗体表现出对包裹病毒的广泛反应性,这表明一种控制病毒威胁的保存机制.
- 这些发现揭示了一种能够防止传染性ERVs出现和传播的自然防御系统.
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