卡里普拉和精神分裂症和双极性障碍患者的认知:系统性审查
Lorena García-Fernández1, Verónica Romero-Ferreiro, Inmaculada Peñuelas-Calvo
1From Clinical Medicine Department, Universidad Miguel Hernández (Dr. García-Fernández); Psychiatry Department, Hospital Universitario de San Juan, Alicante, Spain (Dr. García-Fernández); CIBERSAM-ISCIII (Biomedical Research Networking Centre for Mental Health), Spain (Drs. García-Fernández, Santos, Rodriguez-Jimenez, and Romero-Ferreiro); European University of Madrid (Dr. Romero-Ferreiro); The Research Institute Hospital 12 de Octubre-Imas12 (Drs. Peñuelas-Calvo, Rodriguez-Jimenez, and Romero-Ferreiro), Madrid, Spain; Complutense University of Madrid-UCM (Drs. Peñuelas-Calvo and Rodriguez-Jimenez); Department of Medicine and Medical Specialities, University of Alcala (Dr. Álvarez-Mon); Department of Psychiatry and Mental Health. Hospital Universitario Infanta Leonor (Dr. Álvarez-Mon); Ramón y Cajal Institute of Sanitary Research-IRYCIS (Dr. Álvarez-Mon), Madrid, Spain; Department of Biomedical and Neuromotor Sciences, University of Bologna (Dr. Scala); Faculty of Health Sciences, Universidad Francisco de Vitoria (Dr. Romero-Ferreiro); CIBERESP/ISCIII (Biomedical Research Networking Centre for Epidemiology and PublicHealth/Carlos III Health Institute), Spain (Dr. Romero-Ferreiro); Center for Social and Health Research, University of Castilla-La Mancha (Dr. Jiménez López); Department of Psychiatry, Virgen de La Luz Hospital (Drs. Jiménez López and Santos); Neurobiological Research Group, Technological Institute, University of Castilla-La Mancha (Dr. Santos), Cuenca, Spain.
卡里普拉 (CAR) 在精神分裂症和双相情感障碍患者中显示出认知益处. 与安慰剂和其他治疗方法相比,这种抗精神病药物改善了注意力和认知能力,特别是在较低剂量时.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 卡里普拉辛 (CAR) 是一种具有D3受体部分激动性的抗精神病药物.
- 临床前研究表明,CAR具有前认知效应.
- 本综述侧重于CAR在精神分裂症和双相情感障碍的认知影响.
研究的目的:
- 系统地审查卡里普拉对认知指标的影响.
- 评估CAR在精神分裂症和双相情感障碍患者中的疗效.
主要方法:
- 在主要数据库 (PubMed,科学网,Scopus,Cochrane图书馆) 进行系统搜索,截至2024年5月.
- 包括随机对照试验 (RCT) 来评估CAR的认知影响.
- 使用Jadad尺度进行质量评估.
主要成果:
- 包括5个涉及6104名患者的RCT.
- 与安慰剂相比,CAR改善了精神分裂症和双相情感障碍的认知结果.
- 在注意力任务中,CAR表现出优于RISPERIDONE和ARIPIPRAZOLE的优势.
结论:
- 与安慰剂和其他D2抗剂/部分激动剂相比,卡里普拉 (CAR) 改善了认知指标.
- 在基线损伤较大的患者中,认知益处更为明显.
- 对于精神分裂症和双相情感障碍的认知增强来说,CAR可能是一个有前途的选择,需要使用特定的认知工具进行进一步的研究.
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