利用实施因素和政策来提高纳洛的有效性
Ashly E Jordan1, Mary Brewster, Pamela Mund
1From the New York State Office of Addiction Services and Supports, New York, NY.
Journal of addiction medicine
|November 8, 2024
概括
纳洛是一种经过验证的过量逆转药物,现在可以在非处方药店购买. 扩大获取和支持性法律可以显著减少过量死亡.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 紧急医疗 紧急医疗
背景情况:
- 纳洛在逆转阿片类药物过量服用方面具有50年的有效性和成本效益.
- 美国面临着持续的过量危机,突出了迫切需要可访问的干预措施.
- 鼻内纳洛现在可以在非处方药 (OTC) 和仿制药中获得,这标志着可访问性的重大转变.
研究的目的:
- 突出了扩大公平和持续获得鼻内纳洛的历史性机会.
- 强调将扩大纳洛获取与有效的纳洛获取和善良撒玛利亚人的法律相结合的潜力.
- 为了强调最大限度地提高人口水平的有效性,以可持续地减少过量死亡率的目标.
主要方法:
- 对纳洛有效性和成本效益的历史数据的审查.
- 分析目前作为OTC药物和仿制药的鼻内纳洛的可用性.
- 检查纳洛接入和善良撒玛利亚人的法律在过量预防中的作用.
主要成果:
- 鼻内纳洛现在可以在美国获得OTC,这是自20多年前过量危机开始以来的首次.
- 司法管辖区有很大的机会实施和扩大公平获得这一关键药物的机会.
- 同时颁布和公平实施纳洛获取和善良撒玛利亚人的法律可以增强纳洛的影响.
结论:
- 扩大和公平地获得OTC鼻内纳洛是一种打击正在进行的过量危机的关键策略.
- 将药物获取与支持性法律框架相结合,对于最大限度地提高公共卫生影响至关重要.
- 战略实施可以导致过量服用死亡率的可持续降低.
相关概念视频
Drug Delivery: Enteral Route
383
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
383
Nursing Implementation
4.9K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
4.9K
Analgesia and Pain Management
518
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
518
Drug Control Governance: Regulatory Bodies and Their Impact
142
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
142
Opioid Analgesics: Synthetic and Semisynthetic Opioids
230
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
230
Drug Regulation
1.3K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.3K


