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Updated: Jul 16, 2026

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions
06:01

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

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用分子对接进行理论指导,用于对特定蛋白质检测的高灵敏AIE探针进行选

Kai Zhang1, Shuangxiong Dai1, Zhengxu Cai1

  • 1School of Materials Science and Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.

Talanta
|November 8, 2024
PubMed
概括

本研究引入了一种新的策略,用于设计聚合诱导排放 (AIE) 探针,用于使用分子对接检测蛋白质. 这种计算方法指导开发更有效的AIE探针用于疾病诊断和药物发现.

关键词:
国际环境协会 (AIE) 的探测器.分子设计分子设计.分子对接是分子对接.蛋白质检测检测 蛋白质检测检测

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Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA10:21

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相关概念视频

Immunoprecipitation01:20

Immunoprecipitation

Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.