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Updated: Jun 8, 2025

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在肺腺癌中,FoxA1/2-依赖的表观基因组重编程驱动了血统切换

Katherine Gillis1, Walter A Orellana1, Emily Wilson1

  • 1Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.

Developmental cell
|November 8, 2024
PubMed
概括

癌细胞可以改变身份,影响瘤生长和治疗. 福克斯A1/2蛋白重新编程表观遗传场景,驱使肺癌细胞在失去NKX2-1后采取胃身份,NKX2-1是一个关键的肺细胞调节器.

关键词:
对于FOXA1/2的情况来说,在TET2/3的基础上.癌症血统切换/可塑性 癌症血统切换/可塑性这是表观遗传重编程.肺部腺癌的癌症.

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