性结肠炎患者在进行全关节整形术后,不良事件的风险增加
Oghenewoma P Oghenesume1, Michael J Gouzoulis1, Philip P Ratnasamy1
1Department of Orthopedics & Rehabilitation, Yale School of Medicine, New Haven, Connecticut.
The Journal of arthroplasty
|November 8, 2024
概括
性结肠炎 (UC) 患者接受关节整形手术 (THA) 面临90天不良事件的更高风险. 药物治疗方案,特别是皮质类固醇和免疫调节剂,在接受THA的UC患者中进一步增加了这些风险.
科学领域:
- 整形外科手术 整形外科手术
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 性结肠炎 (UC) 患者接受关节整形手术 (THA) 可能会增加不良事件的风险.
- 对这些风险的UC疾病活动与其治疗的具体贡献尚不清楚.
研究的目的:
- 调查UC和90天术后不良事件和THA后5年生存率之间的关联.
- 评估用于UC的不同药物类别对这些结果的影响.
主要方法:
- 一个大型的行政数据集被用来识别接受THA.的患者.
- 患有UC的患者与没有UC的患者根据年龄,性别和Elixhauser并发症指数相匹配 4:1.
- 包括90天不良事件和5年生存率在内的结果进行了比较,并根据药物类别进行了进一步分析.
主要成果:
- 与非UC患者相比,UC患者的90天不良事件 (任何,严重和轻微) 的几率明显更高.
- 两组之间没有观察到5年生存率的显著差异.
- 不良事件的几率随着UC药物的强度增加,包括皮质类固醇,免疫调节剂和5-氨基酸 (5-ASA).
结论:
- 接受THA治疗的UC患者患有90天术后不良事件的风险增加.
- 由于特定的药物治疗方案,这种风险进一步扩大,强调需要仔细的术后管理.
- 在规划THA时,外科医生应考虑UC状态和药物治疗方案,以优化患者的治疗结果.
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