与糖尿病相关的听力损失中的氧化和内质网膜应激:铁素的保护作用
Meng Xu1, Shiwen Zhong1, Na Zhu1
1Department of Otorhinolaryngology of the Second Hospital, Dalian Medical University, Dalian 116023, LiaoNing Province, China.
Life sciences
|November 8, 2024
概括
铁素 (Trx) 通过减少氧化和内质网膜压力,有望对抗糖尿病相关的听力损失. 这项研究发现Trx有助于保护糖尿病患者和动物模型的听力损伤.
科学领域:
- 耳神经病学 耳神经病学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 糖尿病与复杂的内耳生理变化有关,包括听力损失.
- 氧化应激 (OS) 和内分泌网膜应激 (ERS) 与糖尿病相关的听力损失 (DRHL) 有关.
研究的目的:
- 调查OS和ERS在DRHL中的作用.
- 通过调节OS,ERS和亡来探索雷多克素 (Trx) 在减轻听力损伤方面的潜力.
主要方法:
- 在63名2型糖尿病患者和30名对照组中进行了听力和血清学评估.
- 在野生型和Trx转基因 (Tg) 小鼠中诱导2型糖尿病,与听觉脑干反应 (ABR) 评估.
- 对耳组织分析亡,OS和ERS标记物的分析;在体外研究中使用暴露于高级糖化最终产品 (AGEs) 的HEI-OC1细胞.
主要成果:
- 糖尿病患者和小鼠表现出听力损失,氧化损伤的血清标志物增加.
- 糖尿病小鼠表现出耳毛细胞损失和降低了普雷斯基因表达.
- Trx转基因小鼠在听力损失的进展中表现出显著的延迟;Trx在实验室中的过度表达通过Nrf2激活缓解了AGE诱导的细胞应激.
结论:
- 铁素 (Trx) 显示出对与糖尿病相关的听力损失的保护作用.
- 通过增强Nrf2/HO-1/SOD2通路,Trx可以减轻DRHL,从而降低氧化和内质网膜应激.
相关概念视频
01:46Electron Transport Chain: Complex I and II
11.9K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
11.9K
01:19Psychoneuroimmunology: Diabetes and Cancer
24
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
24
01:31Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
01:26Protein Modifications in the RER
5.0K
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
5.0K
01:36Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K