牛奶过敏的多个方面
Rachelle Lo1, Marion Groetch2, Joel Brooks3
1Department of Allergy, Kaiser Permanente Oakland Medical Center, Oakland, Calif.
The journal of allergy and clinical immunology. In practice
|November 8, 2024
概括
牛奶过敏 (CMA) 在儿童中以各种方式呈现. 诊断依赖于临床病史和特定测试,用水解配方和免疫治疗作为关键的管理策略.
科学领域:
- 儿科 儿科 儿科
- 过敏学 过敏学
- 免疫学 免疫学 免疫学
背景情况:
- 牛奶过敏 (CMA) 是儿童早期流行的一种食物过敏.
- CMA表现出不同的临床表现和诊断复杂性.
- 准确的CMA分类对于适当的管理至关重要.
研究的目的:
- 提供关于牛奶过敏 (CMA) 诊断和管理的全面概述.
- 为了区分IgE介导和非IgE介导的CMA.
- 突出目前基于证据的CMA评估和治疗指南.
主要方法:
- 对CMA分类的临床病史的审查.
- 皮肤刺伤测试和血清特异性IgE对于IgE介导的CMA的诊断效用.
- 临床病史和食道活检用于非IgE介导的CMA诊断.
主要成果:
- 通过IgE介导的CMA诊断可能涉及皮肤刺痛测试,血清特异性IgE和口服食物挑战.
- 非IgE介导的CMA包括食物蛋白质诱导的过敏性前列腺炎,肠球炎综合征和eosinophilic食道炎.
- 在CMA评估中不建议进行Atopy补丁测试,IgG和IgG4测试.
结论:
- 广泛化配方是CMA的主要替代品.
- 口服免疫疗法和奥马利祖马布为IgE介导的CMA提供了替代策略.
- 由于生长风险,对患有CMA的儿童进行营养评估至关重要.
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