尿液中1-西水平,氧化应激和高血压之间的关联:一项针对韩国老年人的小组研究
1Department of Integrative Bioscience & Biotechnology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, 05006, Republic of Korea.
Chemosphere
|November 8, 2024
概括
暴露于多环芳 (PAHs) 会显著增加老年人的血压 (BP),主要是通过氧化应激. 这项研究突出显示了甲酸 (MDA) 在这种关系中的调解作用.
科学领域:
- 环境健康 环境健康
- 心血管健康 心血管健康
- 毒理学 毒理学 毒理学
背景情况:
- 多环芳 (PAH) 是广泛存在的环境致癌物.
- 关于PAH暴露,血压 (BP) 和氧化应激之间的联系的证据有限.
- 氧化应激与各种慢性疾病有关,包括高血压.
研究的目的:
- 在老年人群中调查PAH暴露,氧化应激和血压之间的关联.
- 探索氧化应激在PAH暴露和BP之间的关系中的中介作用.
- 为了确定这些协会中的潜在的性别差异.
主要方法:
- 作为PAH暴露的生物标志物,测量了尿中的1-基烯 (1-OHP).
- 量化尿中马隆迪甲基 (MDA) 作为氧化应激的标志物.
- 在560名老年人 (≥60岁) 中评估了静缩和静缩血压 (SBP/DBP).
主要成果:
- 尿中的1-OHP水平与较高的MDA水平和升高的BP (SBP/DBP) 有显著的关联.
- 尿中MDA水平也与高血压 (SBP/DBP) 有显著的关联.
- 1-OHP和BP之间的关联在老年女性中更为明显,氧化应激 (MDA) 中介96.3%的SBP和94.7%的DBP增加.
结论:
- 暴露于PAH与老年人血压升高有关.
- 由MDA表示的氧化应激在这种关联中起着重要的调解作用.
- 这些发现强调了减少PAH暴露的重要性,以减轻高血压风险,特别是在老年女性等脆弱人群中.
更多相关视频
05:57Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
Published on: May 17, 2024
675
13:59A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
Published on: August 12, 2018
8.1K
相关概念视频
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
01:18Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
60
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
60