在阿片类药物治疗的癌症患者中进行的基因组研究确定了与恶心吐有关的变体
Francesca Minnai1, Morena Shkodra2, Sara Noci3
1Institute for Biomedical Technologies (F.C., F.M.), National Research Council, Segrate, Italy; Department of Medical Biotechnology and Translational Medicine (BioMeTra) (F.M.), Università degli Studi di Milano, Milan, Italy.
Journal of pain and symptom management
|November 8, 2024
概括
这项全基因组关联研究确定了与癌症患者的阿片类药物诱导的恶心和吐相关的遗传标记. 这些发现突出了通过药物基因组学来个性化治疗疼痛的潜力.
科学领域:
- 药物基因组学 药物基因组学
- 癌症 疼痛管理 癌症 疼痛管理
- 遗传学 是一个遗传学.
背景情况:
- 阿片类药物是癌症疼痛的主要治疗方法,但10%-20%的患者经历了不足的缓解或不良反应.
- 对阿片类止痛药的个体反应因遗传因素而异,影响有效性和毒性.
- 阿片类药物诱导的恶心和吐 (NVS) 是一种常见的剂量限制性毒性.
研究的目的:
- 进行全基因组关联研究 (GWAS),以确定与阿片类药物诱导的恶心吐 (NVS) 相关的遗传标记.
- 调查癌症疼痛阿片类药物治疗患者可变反应的遗传基础.
主要方法:
- 招募了来自欧洲的2052名癌症患者,他们接受了吗啡, oxycodone, buprenorphine 或 fentanyl.
- 收集关于NVS,临床信息和基因定型的数据.
- 使用REGENIE软件进行了患者基因型和NVS之间的回归分析.
主要成果:
- 确定了与NVS相关的65种遗传变异 (P值<1.0×10-5).
- 在染色体2上的NPAS2基因中发现了14种与NVS相关的内部变异.
- 指出,NPAS2变体以前与睡眠改变有关,这是另一种阿片类药物副作用,并被确定为拼接定量特征位置.
结论:
- 这是第一个GWAS研究阿片类药物诱导的恶心吐在2000多名癌症患者的遗传因素.
- 研究结果表明,NPAS2基因变异可能在阿片类药物诱导的恶心吐中起作用.
- 强调需要进行大规模的药物遗传学研究,以根据遗传特征量身定制癌症疼痛治疗方法.
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