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怀孕期间呼出的气息挥发性有机化合物:试点研究

Mohsen A A Farghaly¹, Somaya Abuelazm¹, Ruth M Farrell^2,3

¹Neonatology Department, Cleveland Clinic, Cleveland, Ohio.

American journal of perinatology

|November 8, 2024

概括

呼吸中的挥发性有机化合物 (VOC) 可以在孕妇中进行非侵入性测量. 这些VOC在怀孕期间和产后与非怀孕个体相比有显著差异,可能作为生物标志物.

科学领域:

生物化学生物化学
分析化学分析化学
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

挥发性有机化合物 (VOC) 是代谢的副产品.
呼吸分析提供了一种非侵入性的方法来评估生理变化.
了解怀孕期间的VOC概况对于母亲和胎儿的健康至关重要.

研究的目的:

评估孕妇和产后妇女呼出的气息中的挥发性有机化合物 (VOC).
为了将VOC档案与非孕妇对照进行比较.
探索呼吸中的VOCs作为怀孕中的非侵入性生物标志物的潜力.

主要方法:

50名参与者的试点研究:40名孕妇/产后妇女和10名非孕妇对照.
非侵入性收集呼出的呼吸样本.
使用精选离子流管质谱分析22种特定的VOC.

主要成果:

在怀孕和产后期间观察到五种VOC (2-propanol,acrylonitrile,1-nonene,2-nonene,硫化) 的显著差异.
与对照组相比,在每个三个月内都确定了不同的VOC档案.
在非怀孕,怀孕和产后状态中,VOC水平有显著的变化.

结论:

在孕妇中进行呼吸VOC的非侵入性测量是可行的和安全的.
在怀孕和产后期间,呼吸中的VOC概况发生了显著的变化.
这些发现表明VOCs可能作为孕产妇或胎儿疾病的生物标志物,需要进一步调查.

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