治疗直肠癌后患者报告的结果 - 一项前性的全国性研究
Kathinka Schmidt Slørdahl1,2, Aina Balto2, Marianne Grønlie Guren1,3
1Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
患有主要前下切除综合征 (LARS) 或慢性疼痛的直肠癌幸存者经历了显著损害的生活质量. 早期发现和治疗这些疾病对于改善患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 与健康相关的生活质量 (HRQoL)
背景情况:
- 现代直肠癌 (RC) 治疗改善了生存率,但可能导致影响HRQoL的晚期副作用.
- 了解长期功能结果和症状负担对于全面的癌症护理至关重要.
研究的目的:
- 评估诊断后一年的HRQoL和晚期影响,在接受I-III阶段RC大切除的患者中进行评估.
- 为了比较不同患者组之间的功能领域和症状,以及与无癌症的对照组进行比较.
主要方法:
- 一项包括RC患者 (I-III阶段) 和挪威癌症登记处的对照组 (2019-2020) 的队列研究.
- 参与者填写了评估HRQoL和延迟效应的问卷.
- 进行了患者子组之间的统计比较 (例如,根据LARS严重程度,疼痛) 和对照.
主要成果:
- 主要前下切除综合征 (LARS) 影响了60.8%的患者,与较低的功能和较高的症状得分相关.
- 15.4%的患者经历了严重的慢性疼痛,与功能评分较差和症状增加显著相关.
- 与对照组相比,直肠癌患者报告功能得分较低,症状更多.
结论:
- 除了肠道功能障碍或疼痛之外,显著的功能障碍和症状增加与RC幸存者的LARS和慢性疼痛有关.
- 建议对主要LARS和慢性疼痛进行有针对性的识别和管理,以改善患者的HRQoL.
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