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增加的O-GlcNAcylation在病理生理细胞激活过程中将代谢与转录重编程连接起来

Ninon Very1, Bart Staels1, Jérôme Eeckhoute1

  • 1Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France.

Trends in cell biology
|November 8, 2024
PubMed
概括

增加与蛋白质O相关的β-N-乙糖氨基化 (O-GlcNAcylation) 是哺乳动物细胞激活和代谢变化的关键. 这个过程增强了转录调节器,为各种疾病提供了潜在的治疗途径.

关键词:
这是一种O-GlcNAcylation.慢性疾病 慢性疾病代谢重编程是指代谢重编程.病理生理学的细胞激活.转录调节器是指转录调节器.转录性重编程是一种转录性重编程.

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