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在减肥和代谢手术之前,像类-1受体激动剂一样使用葡萄糖的利用模式:一个多中心研究
Shlomi Rayman1, Evyatar Morduch2, Anat Reiner-Benaim3
1Department of General Surgery, Assuta Ashdod Public Hospital, Affiliated with Faculty of Health and Science and Ben-Gurion University, Ashdod, Israel.
概括
葡萄糖类-1受体激动剂 (G1RA) 经常被代谢和减肥手术候选人使用,但往往无法产生显著的体重减轻或由于副作用而停止使用. 需要进一步的研究来优化G1RA在这个人群中的使用.
科学领域:
- 内分泌学 在内分泌学.
- 腹部外科 腹部外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 葡萄糖类-1受体激动剂 (G1RA) 越来越多地用于超重和肥胖个体的体重管理.
- 在代谢和减肥手术 (MBS) 候选人中,G1RA的利用模式和结果尚不清楚.
研究的目的:
- 调查在寻求MBS的个人中使用G1RA的患病率,特征和结果.
- 为了确定与G1RA利用和治疗成功相关的因素,在这个患者群体.
主要方法:
- 追溯分析了来自以色列五个高人数中心的434名MBS候选人的数据 (2023年2月至9月).
- 评估人口统计,临床和治疗数据,包括G1RA病史,不良事件和减肥结果.
主要成果:
- 63%的MBS候选人之前使用过G1RA (利拉格卢提德,西马格卢提德最常见).
- 使用G1RA与年龄较小,2型糖尿病,脂质失调和没有先前的MBS病史有关.
- 在19周内,平均最大体重减轻为5.38公斤;57.8%的人报告了胃肠道不良事件,导致超过95%的病例由于疗效不足或副作用而停止治疗.
- 达到最大G1RA剂量与显著增加的体重减轻相关.
结论:
- 在MBS前使用G1RA是常见的,但通常以有限的疗效和高的断药率为特征.
- 对于有效的肥胖管理,需要对MBS候选人适当使用G1RA进行进一步的研究和指导方针.
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