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相关概念视频

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
8.8K
Olfaction01:25

Olfaction

44.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.2K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.1K

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相关实验视频

Updated: Jun 8, 2025

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
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The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

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在3D重建中可视化人类的嗅觉投影和辅助结构.

Victoria F Low1, Chinchien Lin2, Shan Su2

  • 1Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.

Communications biology
|November 8, 2024
PubMed
概括

研究人员使用先进的成像和人工智能创建了人类嗅觉系统的3D模型. 这种详细的可视化显示了大约270万个嗅觉感官神经元 (OSN),有助于与其他物种进行比较研究.

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Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
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A Free-breathing fMRI Method to Study Human Olfactory Function
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Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
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科学领域:

  • 神经科学是一个神经科学.
  • 人体解剖学 解剖学 解剖学
  • 历史学 历史学 历史学

背景情况:

  • 了解人类嗅觉系统的微解剖学是复杂的,因为需要大量的组织部分.
  • 以前的方法缺乏全面的3D可视化功能,用于详细的嗅道分析.

研究的目的:

  • 开发一个工作流程,用于人类嗅觉投影的3D重建和可视化.
  • 量化嗅觉感官神经元 (OSN) 并将人类的嗅觉组织与其他物种进行比较.

主要方法:

  • 一个7.45厘米3的人类嗅觉标本被切割 (10微米),用四倍光染色,并扫描.
  • 卷积神经网络被训练为六个关键结构的自动细分.
  • 一个高性能计算解决方案被用于截面注册和3D模型组装.

主要成果:

  • 成功生成了人类嗅觉投影的详细3D重建.
  • 该研究估计样本中大约有270万个嗅觉感官神经元 (OSN).
  • 3D可视化提供了新的交互式和虚拟探索工具.

结论:

  • 开发的工作流程使人类嗅觉微解剖学的详细3D可视化成为可能.
  • 对OSN数量的实证数据为将人类的嗅觉组织与小鼠的嗅觉组织进行比较提供了基础.
  • 这项研究为嗅觉系统教育提供了重要的教学潜力.