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Updated: Jun 8, 2025

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
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The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

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在3D重建中可视化人类的嗅觉投影和辅助结构.

Victoria F Low1, Chinchien Lin2, Shan Su2

  • 1Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.

Communications biology
|November 8, 2024
PubMed
概括

研究人员使用先进的成像和人工智能创建了人类嗅觉系统的3D模型. 这种详细的可视化显示了大约270万个嗅觉感官神经元 (OSN),有助于与其他物种进行比较研究.

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Olfactory Receptors: Location and Structure01:03

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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