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针对TAMs:我们能比癌细胞更聪明吗?
Julia Kzhyshkowska1,2,3,4, Jiaxin Shen5,6, Irina Larionova7,8,9
1Department of Innate Immunity and Tolerance, Institute of Transfusion Medicine and Immunology, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, 1-3, 68167, Mannheim, Germany. julia.kzhyshkowska@medma.uni-heidelberg.de.
Cellular & molecular immunology
|November 8, 2024
概括
与瘤相关的巨细胞 (TAMs) 驱动癌症的进展和治疗阻力. 通过各种策略,如抑制它们的生存或重新编程它们的功能,准TAM为癌症治疗提供了有希望的新途径.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 癌症仍然是全球主要的死亡原因,影响生活质量并导致残疾.
- 有效的癌症治疗需要了解和操纵天生的免疫系统,特别是瘤相关巨细胞 (TAMs).
研究的目的:
- 审查TAM亚群及其生物标志物在癌症进展和治疗耐药性中的作用.
- 探索调节TAM功能的新机制,包括通过基因组乳化进行表观遗传编程.
- 总结有关TAM向癌症治疗的当前临床试验数据.
主要方法:
- 对TAM亚群和生物标志物的累积证据的审查.
- 对TAM歧视的单细胞和空间分析方法的分析.
- 检查TAMs中的表观遗传,信号,转录和代谢途径之间的交叉交互.
- 根据治疗策略分类的临床试验数据的摘要.
主要成果:
- TAMs是瘤进展和对治疗的耐药性的关键调节者.
- 生物标志物可以预测固体癌症的临床参数和治疗耐药性.
- 基斯乳化将癌细胞代谢与前性TAM编程联系起来.
- TAMs干扰现有的癌症治疗方法,需要新的策略.
结论:
- 针对TAMs对于推进癌症治疗至关重要.
- 策略包括抑制TAM生存/招募,重编程TAM和遗传增强.
- 了解TAM异质性和编程对于个性化癌症治疗至关重要.
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