不同的组织形态学分级系统的比较在皮状细胞癌中
Gilbert Georg Klamminger1,2, Annick Bitterlich3,4, Meletios P Nigdelis5
1Department of General and Special Pathology, Saarland University (USAAR), 66424, Homburg, Germany. gilbert-georg.klamminger@uks.eu.
Archives of gynecology and obstetrics
|November 8, 2024
概括
布莱恩的分级系统显示了HPV相关的癌的预后相关性,与淋巴结转移相关. 这种系统推用于组织病理学报告,以改善预后解释和指导未来的研究.
科学领域:
- 妇科瘤学 妇科瘤学
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 像布罗德和布莱恩这样的已建立的组织病理学分级系统对于癌症预后至关重要.
- 然而,目前尚缺少一种标准化,具有预后意义的皮细胞癌的分级系统.
- 大多数研究都集中在头部和部或口腔癌.
研究的目的:
- 评估布罗德和布莱恩分级系统与沟淋巴结转移在癌的预后关联.
- 为了研究HPV-association在这些预后关系中的作用.
主要方法:
- 对73例外阴癌病例的回顾性分析.
- 应用布罗德和布莱恩的分级系统.
- 免疫组织化学p16染色用于HPV亚分类.
- 统计分析包括斯皮尔曼相关性,后勤回归,概率比测试 (LRT) 和ROC/AUC分析.
主要成果:
- 布莱恩的二年级是最常见的评分 (66%).
- 布莱恩的分级与hpv相关的 vulvar carcinomas中的淋巴结参与有积极的相关性.
- 布莱恩的分级证明了预测淋巴结转移的可行性 (LRT p=0.0066,AUC ≈ 0.91).
- 在目前的分级系统中,HPV独立的瘤没有得到足够的特征.
结论:
- 布莱恩的分级系统显示了与HPV相关的阴道状细胞癌的显著预后价值,特别是在淋巴结转移方面.
- 建议将布莱恩的分级纳入 vulvar carcinomas 的组织病理学报告.
- 这种纳入将加强预后解释,并促进未来的研究.
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