采用非侵入性方法精确进行结肠直肠癌查
Han-Mo Chiu1, Takahisa Matsuda2
1Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan. hanmochiu@ntu.edu.tw.
Digestive diseases and sciences
|November 8, 2024
概括
有效的结肠直肠癌 (CRC) 查至关重要. 像便免疫化学测试 (FIT) 这样的非侵入性测试显示出希望,但需要使用大数据和人工智能的个性化策略,以更好地分层风险和查效率.
科学领域:
- 胃肠道学和瘤学
- 预防医学 预防医学
- 生物技术是生物技术.
背景情况:
- 结肠镜对于结肠直肠癌 (CRC) 检测很敏感,但成本昂贵且具有侵入性.
- 像便免疫化学测试 (FIT) 这样的非侵入性测试提供了更好的接受度和成本效益的替代方案.
- 新兴的非侵入性测试 (便DNA/RNA,血液ctDNA) 显示出潜力,但面临成本和特异性挑战.
研究的目的:
- 审查当前的CRC查策略,重点关注非侵入性方法.
- 探索便血红蛋白度的潜力,以量身定制查间隔和风险分层.
- 讨论现实数据和先进技术在提高CRC查准确性方面的作用.
主要方法:
- 审查关于CRC查方式的当前文献.
- 分析非侵入性查试验的优点和局限性.
- 讨论个人化查策略,包括大数据,人工智能和数字双胞胎.
主要成果:
- 由于其敏感性,成本和接受度的平衡,FIT是首选的非侵入性查方法.
- 风险因素和查行为中的人口异质性使统一的CRC查有效性复杂化.
- 定量FIT测量和与现实世界大数据的整合为改善人口查提供了一种可行的方法.
结论:
- 个性化查策略是必要的,以解决CRC风险和查行为中的人口异质性.
- 将定量FIT与现实世界的大数据相结合,是提高CRC查效率的实际步骤.
- 像人工智能和数字双胞胎这样的先进技术有可能在未来优化CRC查,等待验证和成本效益分析.
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