老年人的喘和认知功能障碍:系统性免疫炎症指数的调解作用
Jianqin Hu1, Honggang Ma1, Zhiyuan Ning2
1Department of Neurology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, 1558 Third Ring North Road, Huzhou, 313000, Zhejiang, P. R. China.
Scientific reports
|November 8, 2024
概括
患有喘的老年人表现出对认知功能障碍的倾向. 系统性免疫炎症指数 (SII) 在这种联系中起着调解作用,这表明喘可能通过炎症影响认知.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 喘和认知功能障碍是老年人的重大公共卫生问题.
- 了解喘和认知衰退之间的联系对于有针对性的干预至关重要.
研究的目的:
- 调查60岁及以上成年人喘和认知功能障碍之间的关联.
- 探索系统性免疫炎症指数 (SII) 在喘-认知功能障碍关系中的调解作用.
主要方法:
- 从NHANES 2011-2014年对2579名参与者 (年龄≥60岁) 的回顾性横截面研究.
- 喘通过MCQ010进行评估;通过数字符号替换测试 (DSST) 测量认知功能.
- 系统性免疫炎症指数 (SII) 计算为 (血小板数 × 中性粒细胞数) / 淋巴细胞数.
主要成果:
- 在喘和DSST得分之间发现了负相关性 (β = -1.75,P = 0.037),在BMI和糖尿病 (β = -1.72,P = 0.043) 的调整后仍然存在.
- 亚组分析显示,性别,年龄,种族/种族,BMI或糖尿病对喘-认知功能关系没有显著的影响.
- 调解分析表明,SII显著调解了喘和认知功能障碍之间的联系 (ACME,P=0.004).
结论:
- 患有喘的老年人倾向于认知功能障碍,独立于常见的人口和健康因素.
- 系统性免疫炎症指数 (SII) 成为一个关键的调解者,表明喘通过炎症途径导致认知障碍.
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