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Updated: Jun 8, 2025

Purification of Hsp104, a Protein Disaggregase
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一个蛋白质溶解的AAA+机器准备展开蛋白质基板

Alireza Ghanbarpour1,2, Robert T Sauer3, Joseph H Davis4

  • 1Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St Louis, 63130, USA.

Nature communications
|November 8, 2024
PubMed
概括

像ClpXP这样的AAA+蛋白酶使用通过降解尾巴抓住基质的ClpX六合体来展开蛋白质. 新的冷EM结构揭示了这种机器在蛋白质展开和降解中的关键中间体.

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