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Updated: Jun 8, 2025

Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
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基于哺乳动物细胞的甘氨酸,糖和糖模块的生产

Thapakorn Jaroentomeechai1, Richard Karlsson1, Felix Goerdeler1

  • 1Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Nature communications
|November 8, 2024
PubMed
概括

这项研究介绍了Glycocarriers,这是一种可持续的方法,用于在工程细胞中生产各种人类甘氨酸. 这项技术为生物医学研究和应用提供了可扩展的glycans访问.

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Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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