意大利日诺瓦的恶性脑瘤的流行病学. 1993年至2017年期间的时间
Guido Frosina1, Claudia Casella2, Antonella Puppo2
1Mutagenesis & Cancer Prevention, IRCCS Ospedale Policlinico San Martino, 16132, Genova, Italy. guidofrosina7@gmail.com.
Scientific reports
|November 8, 2024
概括
这项研究分析了1993-2017年意大利日诺瓦的原发性脑瘤发病率. 质母细胞瘤的发病率增加,这可能是由于诊断的改进,因此需要进一步研究环境危险因素.
科学领域:
- 神经瘤学神经瘤学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 初级脑瘤是一个重大的公共卫生问题.
- 了解发病率趋势对于资源配置和研究至关重要.
- 意大利日诺瓦为这一流行病学分析提供了特定的地理重点.
研究的目的:
- 更新基诺瓦大都会地区初级脑瘤发病率的分析.
- 计算各种脑瘤类型的发病率,包括质母细胞瘤.
- 确定25年 (1993-2017) 期间发病率的趋势和变化.
主要方法:
- 对恶性脑瘤,质母细胞瘤和其他指定的/未指定的脑瘤病例数和发病率的分析.
- 从1993年到2017年,数据分为七个三年期和一个四年期.
- 年龄调整率 (AAR) 计算使用2013年欧洲标准人口,每10万人/年.
- 计算了三年期间的平均百分比变化.
主要成果:
- 在整个研究期间,恶性脑瘤和质母细胞瘤的发病率在男性中高于女性.
- 整体脑瘤发病率显示微小的变化 (平均3年变化为0.6%).
- 质母细胞瘤发病率显著增加 (平均3年变化5.3%),可能与诊断准确度的提高有关.
- 其他恶性或未指定的脑瘤的减少表明了诊断的转变.
结论:
- 观察到质母细胞瘤发病率的增加可能部分归因于诊断灵敏度和特异性的提高.
- 对质母细胞瘤的潜在环境风险因素进行进一步的研究,例如在日诺瓦暴露于电离辐射,是有必要的.
- 对脑瘤的流行病学监测对于公共卫生倡议至关重要.
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