芳香酶抑制剂和骨折预防 - 2017年指南在现实世界中是否有效?
Anem Mirza1, Zeyar Win Naing2, Parisa Khonsari2
1University College Hospital, 235 Euston Road., London, NW1 2BU, UK.
BJC reports
|November 8, 2024
概括
2017年的指导方针显著减少了服用芳酶抑制剂治疗乳腺癌的妇女的骨折,从13%降至2.5%. 这种现实世界的证据支持采用这些指导方针来改善患者的治疗结果并减少医疗保健负担.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 芳香酶抑制剂 (AIs) 对于乳腺癌治疗至关重要,提高了生存率.
- 然而,AI会导致骨质损失 (AIBL),增加骨折风险.
- 现有的指导方针旨在减轻这种不利影响.
研究的目的:
- 评估2017年关于管理芳酶抑制剂诱导的骨质损失 (AIBL) 的共识指南的实际有效性.
- 评估2017年指南对接受乳腺癌人工智能治疗的女性骨折预防的影响.
主要方法:
- 一项长达7年的研究涉及1001名女性,他们被处方给了AI.
- 第1组:按照2008年国家骨质疏松学会 (NOS) 的指导方针进行管理.
- 组2:按照2017年共识指南进行管理.
主要成果:
- 2017年指导方针组显示,与2008年指导方针组相比 (13%),骨折显著减少 (2.5%).
- 这代表了骨折的绝对风险降低10.5%.
- 2017年的指导方针也导致骨质疏松症的骨活性治疗率较高 (39%对25%).
结论:
- 2017年达成共识的指导方针有效地减少了女性在AI的现实临床实践中的断裂.
- 实施2017年指导方针可以显著降低患者的发病率,并对医疗保健系统产生积极影响.
- 建议乳腺癌专家采用2017年指南,以改善患者的长期骨健康.
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