母胎肠道和羊水微生物群的变化与胎儿生长限制相关
Yuanling Xiao1, Meng Li2,3, Shaoping Zheng2
1Department of Fetal Medicine and Prenatal Diagnosis, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
BMC pregnancy and childbirth
|November 8, 2024
概括
母亲肠道微生物群的改变与胎儿生长限制 (FGR) 有关. 这项研究确定了与FGR相关的母体肠道,羊水和胎儿肠道中的特定细菌变化,提供了新的诊断见解.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 基因组学就是基因组学.
背景情况:
- 胎儿生长限制 (FGR) 会影响胎儿的发育.
- 母亲的肠道微生物群在FGR中发挥着作用.
- 在FGR中对母胎和子宫内微生物群的研究有限.
研究的目的:
- 调查FGR中的母胎肠道和子宫内微生物群.
- 确定与FGR相关的细菌分类学和功能变化.
- 开发用于FGR的诊断生物标志物.
主要方法:
- 案例控制研究的设计.
- 细菌16S rRNA对母体便,和羊水样本的测序.
- FGR和健康对照组之间的微生物群的比较.
主要成果:
- 在羊水,母体便和中确定了差异化的操作分类学单位 (OTU).
- FGR受试者在母亲的肠道中显示出丰富的Bacteroides,在羊水中显示出枯竭的Enterobacterales/Pseudomonas.
- 改变的OTU与新生儿体重和胎儿超声波指数相关;在母体肠道中确定了微生物功能途径的差异.
结论:
- 在FGR中对母胎肠道和羊水中的微生物转移的全面概述.
- 对FGR开发和选的新见解.
- 需要进一步的研究来评估污染对美和羊水的影响.
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