在中年2型糖尿病患者中,时间范围与认知障碍的关联
Yanting Liu1,2, Yanlan Liu3, Huina Qiu3
1Tianjin Medical University, Tianjin, China.
BMC endocrine disorders
|November 8, 2024
概括
在患有2型糖尿病 (T2DM) 的中年成年人中,保持在70%以上的时间范围 (TIR) 可能会防止认知障碍. 较低的TIR水平与这一群体认知能力下降的风险增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 2型糖尿病 (T2DM) 是一种与认知障碍 (CI) 相关的普遍疾病.
- 血糖监测 (BGM) 提供了关于血糖控制的见解,包括时间范围 (TIR).
- 中年T2DM患者的TIR和认知功能之间的关系需要进一步研究.
研究的目的:
- 在中年T2DM患者中研究TIR和CI之间的关联.
- 确定实现>70%的TIR目标是否对这一人口群体的认知功能产生保护作用.
主要方法:
- 一项横截面研究包括274名年龄在40-64岁的T2DM住院患者.
- 七点BGM数据被用于计算TIR (目标范围:3.9-10.0 mmol/L).
- 用蒙特利尔认知评估 (MoCA) 和迷你精神状态检查 (MMSE) 评估认知功能,将参与者分为正常认知功能 (NCF) 和CI组.
主要成果:
- 研究人群中CI的患病率为41.6% (平均年龄为58岁).
- 与NCF患者相比,CI患者的TIR显著降低 (28.6%与42.9%,P=0.004).
- 后勤回归显示较低的TIR和CI (OR=0.84,P<0.001) 之间存在显著的关联,即使对混因素进行了调整. >70%的TIR目标显示了保护作用 (OR=0.25,P=0.001).
结论:
- 来自BGM的时间范围 (TIR) 与T2DM中年个体的认知障碍有显著的关联.
- 超过70%的TIR目标似乎对这个患者群体的认知功能有保护作用.
- 这些发现强调了优化血糖控制在目标范围内的重要性,以保持中年T2DM患者的认知健康.
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